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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:vascular endothelial growth factor signaling pathway
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Accession:PW:0000243 term browser browse the term
Definition:The VEGF family plays key roles in angiogenesis and lymphangiogenesis. Through their receptors, VEGFs can initiate a diverse and complex network of signaling cascades. Deregulation of VEGF-mediated pathways, mostly through upregulation of VEGF expression, has been implicated in a number of conditions, primarily cancer.
Synonyms:related_synonym: Signaling by VEGF;   VEGF signaling pathways;   vascular endothelial growth factor receptor signaling pathway
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vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP1 A-kinase anchoring protein 1 ISO PID PID:200188 NCBI chr16:36,275,287...36,313,612
Ensembl chr16:36,275,209...36,306,012 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO PID PID:200188 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G ARF1 ADP ribosylation factor 1 ISO PID PID:200188 NCBI chr25:1,628,836...1,644,502
Ensembl chr25:1,628,751...1,644,499 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200188 NCBI chr21:109,495,525...109,690,261 JBrowse link
G CALM1 calmodulin 1 ISO PID PID:200188 NCBI chr24:68,133,446...68,145,117
Ensembl chr24:68,133,428...68,145,180 		JBrowse link
G CALM2 calmodulin 2 ISO PID PID:200188 NCBI chr14:60,027,884...60,042,041
Ensembl chr14:60,027,801...60,044,951
Ensembl chr 6:60,027,801...60,044,951
Ensembl chr24:60,027,801...60,044,951 		JBrowse link
G CALM3 calmodulin 3 ISO PID PID:200188 NCBI chr 6:39,957,012...39,966,562
Ensembl chr 6:39,957,320...39,966,581
Ensembl chr24:39,957,320...39,966,581
Ensembl chr14:39,957,320...39,966,581 		JBrowse link
G CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 ISO PID PID:200188 NCBI chr11:116,613,003...116,648,389
Ensembl chr11:116,615,996...116,653,261 		JBrowse link
G CAV1 caveolin 1 ISO PID PID:200188 NCBI chr21:85,222,724...85,258,562
Ensembl chr21:85,222,879...85,258,627 		JBrowse link
G CBL Cbl proto-oncogene ISO PID PID:200188 NCBI chr 1:110,581,049...110,679,284
Ensembl chr 1:110,581,143...110,674,481 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:14693680 RGD:1580560 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CDC42 cell division cycle 42 ISO PID PID:200188 NCBI chr20:110,568,004...110,608,318
Ensembl chr20:110,569,352...110,582,562 		JBrowse link
G CDH5 cadherin 5 ISO PID PID:200188 NCBI chr 5:52,059,987...52,098,595
Ensembl chr 5:52,060,013...52,100,405 		JBrowse link
G CTNNA1 catenin alpha 1 ISO PID PID:200188 NCBI chr23:41,423,504...41,599,458
Ensembl chr23:41,447,675...41,600,190 		JBrowse link
G CTNNB1 catenin beta 1 ISO PID PID:200188 NCBI chr22:2,679,488...2,725,034
Ensembl chr22:2,684,022...2,723,949 		JBrowse link
G DNM2 dynamin 2 ISO PID PID:200188 NCBI chr 6:9,718,014...9,830,061
Ensembl chr 6:9,718,244...9,831,206 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:14597660 RGD:1334466 NCBI chr25:68,624,754...68,685,961
Ensembl chr25:68,625,260...68,682,804 		JBrowse link
G EGLN2 egl-9 family hypoxia inducible factor 2 ISO RGD PMID:12876291 PMID:14597660 PMID:15563310 RGD:1334463 RGD:1334466 RGD:727754 NCBI chr 6:35,251,247...35,263,717
Ensembl chr 6:35,251,237...35,260,040 		JBrowse link
G FBXW11 F-box and WD repeat domain containing 11 ISO PID PID:200188 NCBI chr23:74,015,964...74,154,285
Ensembl chr23:74,015,964...74,154,062 		JBrowse link
G FES FES proto-oncogene, tyrosine kinase ISO PID PID:200188 NCBI chr29:8,967,542...8,979,475
Ensembl chr29:8,965,997...8,979,361 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO RGD
PID		 PMID:15785231 PMID:16633338 PID:200109 PID:200188 RGD:1626621 RGD:2298727 NCBI chr 3:7,412,506...7,608,122
Ensembl chr 3:7,412,172...7,607,967 		JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 ISO Mutatons in VEGFR-3 have been implicated in lymphedema
This is VGFR-3		 RGD
PID		 PMID:11683876 PMID:15563310 PMID:16633338 PID:200109 RGD:1334463 RGD:2298727 RGD:727326 NCBI chr23:82,328,257...82,373,785
Ensembl chr23:82,328,258...82,357,044 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO PID
RGD		 PMID:17658244 PID:200188 RGD:2298729 NCBI chr13:61,988,265...62,218,756
Ensembl chr13:62,159,874...62,219,672 		JBrowse link
G GAB1 GRB2 associated binding protein 1 ISO PID PID:200188 NCBI chr 7:90,197,374...90,323,024
Ensembl chr 7:90,197,620...90,322,077 		JBrowse link
G GRB10 growth factor receptor bound protein 10 ISO PID PID:200188 NCBI chr21:8,022,483...8,225,339
Ensembl chr21:8,063,238...8,225,664 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO PID PID:200188 NCBI chr16:46,264,818...46,346,426
Ensembl chr16:46,264,825...46,347,156 		JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate ISO PID PID:200188 NCBI chr16:73,613,711...73,632,527
Ensembl chr16:73,613,786...73,632,016 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO RGD PMID:9398602 PMID:15563310 PMID:18614764 RGD:1334463 RGD:2301848 RGD:625724 NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200188 NCBI chr24:80,016,352...80,019,130
Ensembl chr24:80,016,232...80,019,120 		JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO PID PID:200188 NCBI chr17:27,914,261...27,921,666
Ensembl chr17:27,911,013...27,921,251 		JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 ISO PID PID:200188 NCBI chr29:9,363,273...9,485,644
Ensembl chr29:9,362,926...9,485,526 		JBrowse link
G ITGAV integrin subunit alpha V ISO PID PID:200188 NCBI chr10:72,125,710...72,216,757
Ensembl chr10:72,125,962...72,216,809 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO PID PID:200188 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
G KDR kinase insert domain receptor ISO VEGFR-2 RGD
PID		 PMID:9442048 PMID:15563310 PMID:15785231 PMID:16633338 PMID:17658244 More... PID:200109 PID:200188 RGD:1334463 RGD:1626621 RGD:2292019 RGD:2298727 RGD:2298729 RGD:2301848 RGD:729081 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO PID PID:200188 NCBI chr26:17,059,122...17,168,787
Ensembl chr26:17,060,054...17,168,782 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 ISO PID PID:200188 NCBI chr 6:3,848,441...3,881,367
Ensembl chr 6:3,848,401...3,881,412 		JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 ISO PID PID:200188 NCBI chr16:19,396,377...19,427,617
Ensembl chr16:19,396,452...19,427,652 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO PID PID:200188 NCBI chr16:52,045,398...52,188,416
Ensembl chr16:52,057,784...52,187,997 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO PID PID:200188 NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 ISO PID PID:200188 NCBI chr19:32,754,261...32,760,859
Ensembl chr19:32,752,546...32,760,798 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO PID PID:200188 NCBI chr17:36,012,164...36,095,542
Ensembl chr17:36,014,454...36,095,138 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO PID PID:200188 NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461 		JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 ISO PID PID:200188 NCBI chr25:22,632,180...22,681,250
Ensembl chr25:22,629,729...22,681,373 		JBrowse link
G MYOF myoferlin ISO PID PID:200188 NCBI chr 9:86,550,688...86,730,213
Ensembl chr 9:86,551,128...86,703,466 		JBrowse link
G NCK1 NCK adaptor protein 1 ISO RGD
PID		 PMID:17658244 PID:200188 RGD:2298729 NCBI chr15:53,501,152...53,595,500
Ensembl chr15:53,500,623...53,523,576 		JBrowse link
G NCK2 NCK adaptor protein 2 ISO PID PID:200188 NCBI chr14:9,412,677...9,515,565
Ensembl chr14:9,437,301...9,515,561 		JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase ISO PID PID:200188 NCBI chr26:27,487,652...27,655,742
Ensembl chr26:27,487,796...27,655,992 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO PID PID:200188 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NRP1 neuropilin 1 ISO RGD
PID		 PMID:15563310 PMID:16633338 PID:200109 RGD:1334463 RGD:2298727 NCBI chr 9:32,474,787...32,632,746
Ensembl chr 9:32,474,309...32,633,101 		JBrowse link
G NRP2 neuropilin 2 ISO PID PID:200109 NCBI chr10:91,460,179...91,575,408
Ensembl chr10:91,460,373...91,557,430 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 ISO PID PID:200188 NCBI chr15:90,474,367...90,488,814
Ensembl chr15:90,398,660...90,449,346
Ensembl chr15:90,398,660...90,449,346 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200188
G PGF placental growth factor ISO RGD PMID:7706320 PMID:16633338 RGD:2298727 RGD:633657 NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200188 NCBI chr15:10,218,034...10,304,874
Ensembl chr15:10,218,805...10,294,316 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200188 NCBI chr 4:64,321,296...64,406,188
Ensembl chr 4:64,321,078...64,406,519 		JBrowse link
G PLCG1 phospholipase C gamma 1 ISO RGD
PID		 PMID:17658244 PID:200188 RGD:2298729 NCBI chr 2:22,599,547...22,638,394 JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO PID PID:200188 NCBI chr 4:39,516,307...39,553,627 JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO PID PID:200188 NCBI chr20:76,258,063...76,319,512
Ensembl chr20:76,259,763...76,319,430 		JBrowse link
G PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO PID PID:200188 NCBI chr11:115,008,306...115,021,348
Ensembl chr11:115,008,313...115,023,373 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200188 NCBI chr 6:12,743,752...12,759,155 JBrowse link
G PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO PID PID:200188 NCBI chr11:45,243,199...45,262,143
Ensembl chr11:45,243,823...45,260,396 		JBrowse link
G PRKCA protein kinase C alpha ISO PID
RGD		 PMID:17658244 PID:200188 RGD:2298729 NCBI chr16:54,638,548...55,144,372
Ensembl chr16:54,642,729...54,948,256 		JBrowse link
G PRKCB protein kinase C beta ISO RGD PMID:17658244 RGD:2298729 NCBI chr 5:21,558,608...21,940,536
Ensembl chr 5:21,558,441...21,943,864 		JBrowse link
G PRKCD protein kinase C delta ISO RGD
PID		 PMID:15541367 PID:200188 RGD:2298730 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:17658244 RGD:2298729 NCBI chr20:129,367,309...129,502,681
Ensembl chr20:129,365,679...129,485,818 		JBrowse link
G PTK2 protein tyrosine kinase 2 ISO RGD PMID:17658244 RGD:2298729 NCBI chr 8:134,897,511...135,246,300 JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO PID PID:200188 NCBI chr 8:25,437,680...25,571,594
Ensembl chr 8:25,437,564...25,571,782 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200188 NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200188 NCBI chr11:6,977,480...6,994,525
Ensembl chr11:6,984,710...6,994,545 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J ISO PID PID:200188 NCBI chr 1:17,137,896...17,328,836
Ensembl chr 1:17,135,907...17,328,590 		JBrowse link
G PXN paxillin ISO PID PID:200188 NCBI chr11:115,560,859...115,619,093
Ensembl chr11:115,560,662...115,619,029 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200188 NCBI chr22:48,560,270...48,643,537
Ensembl chr22:48,561,161...48,618,020 		JBrowse link
G RHOA ras homolog family member A ISO PID PID:200188 NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 ISO PID PID:200188 NCBI chr18:59,384,822...59,538,780
Ensembl chr18:59,384,944...59,540,070 		JBrowse link
G SH2D2A SH2 domain containing 2A ISO RGD
PID		 PMID:17658244 PID:200188 RGD:2298729 NCBI chr20:7,052,170...7,063,262
Ensembl chr20:7,052,797...7,062,324 		JBrowse link
G SHB SH2 domain containing adaptor protein B ISO RGD
PID		 PMID:17658244 PID:200188 RGD:2298729 NCBI chr12:42,520,803...42,669,892
Ensembl chr12:42,520,905...42,669,211 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200188 NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776 		JBrowse link
G VCL vinculin ISO PID PID:200188 NCBI chr 9:57,253,219...57,375,947
Ensembl chr 9:57,255,166...57,376,028 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:12181492 PMID:15563310 PMID:15785231 PMID:16160062 PMID:16633338 More... RGD:1334463 RGD:1626621 RGD:2292019 RGD:2298727 RGD:2301848 RGD:2301956 RGD:625593 NCBI chr17:28,377,959...28,394,508 JBrowse link
G VEGFB vascular endothelial growth factor B ISO RGD PMID:16633338 RGD:2298727 NCBI chr 1:9,997,820...10,001,518
Ensembl chr 1:9,997,665...10,001,429 		JBrowse link
G VEGFC vascular endothelial growth factor C ISO RGD
PID		 PMID:11683876 PMID:15563310 PMID:16633338 PID:200109 RGD:1334463 RGD:2298727 RGD:727326 NCBI chr 7:122,772,539...122,893,486
Ensembl chr 7:122,772,182...122,893,512 		JBrowse link
G VEGFD vascular endothelial growth factor D ISO This is the VEGF-D RGD
PID		 PMID:11683876 PMID:15563310 PMID:16633338 PID:200109 RGD:1334463 RGD:2298727 RGD:727326 NCBI chr  X:13,813,472...13,854,253
Ensembl chr  X:13,813,403...13,854,057 		JBrowse link
G VTN vitronectin ISO PID PID:200188 NCBI chr16:22,133,903...22,138,077
Ensembl chr16:22,133,138...22,136,815 		JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT4 fms related receptor tyrosine kinase 4 ISO RGD PMID:15563310 RGD:1334463 NCBI chr23:82,328,257...82,373,785
Ensembl chr23:82,328,258...82,357,044 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KDR kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr17:28,377,959...28,394,508 JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT4 fms related receptor tyrosine kinase 4 ISO RGD PMID:15563310 RGD:1334463 NCBI chr23:82,328,257...82,373,785
Ensembl chr23:82,328,258...82,357,044 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr17:28,377,959...28,394,508 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    signaling pathway 1932
      growth factor signaling pathway 370
        vascular endothelial growth factor signaling pathway 83
          altered vascular endothelial growth factor signaling pathway + 3
Path 2
Term Annotations click to browse term
  pathway 4034
    regulatory pathway 2500
      homeostasis pathway 1295
        cardiovascular system homeostasis pathway 263
          vascular endothelial growth factor signaling pathway 83
            altered vascular endothelial growth factor signaling pathway + 3
paths to the root